If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

This chapter will be devoted to the itinerary of classical German thought, and especially Hegel, in Merleau-Ponty’s thought. I begin by examining Merleau-Ponty’s initial use of Hegel’s systematic and metaphysicalmetaphysics ideas in phenomenological analyses of behavior and perception. Next, I examine Merleau-Ponty’s role in controversies regarding the existentialists’ interpretation and objections to Hegel’s system. I trace his attempts to surmount antinomiesantinomy between subjectivitysubjectivity and system that emerged in the existentialist’s anthropological reading of Hegel. Here Merleau-Ponty focused on linguistics and more (...) general analyses of institution and expression. Finally, I will view the renewed role that classical German philosophy, including Schelling and Hegel, played in his final works. Still reflecting these interests, his writings and lectures engaged in a wide-ranging dialogue with contemporary aesthetics, sciencescience, and philosophy, culminating in an attempt to formulate a new ontologyontology. (shrink)

This book is a study of the philosophy of the early 18th century Irish philosopher George Berkeley in the intellectual context of his times, with a particular focus on how, for Berkeley, mind is related to its ideas. It does not assume that thinkers like Descartes, Malebranche, or Locke define for Berkeley the context in which he develops his own thought. Instead, he indicates how Berkeley draws on a tradition that informed his early training and that challenges much of the (...) early modern thought with which he is often associated. Specifically, the book indicates how Berkeley's distinctive treatment of mind (as the activity whereby objects are differentiated and related to one another) highlights how mind neither precedes the existence of objects nor exists independently of them. This distinctive way of understanding the relation of mind and objects allows Berkeley to appropriate ideas from his contemporaries in a manner that transforms the issues with which he is engaged. The resulting insights--for example, about how God creates the minds that perceive objects--are only now starting to be fully appreciated. (shrink)

We present three experiments using a novel problem in which participants update their estimates of propensities when faced with an uncertain new instance. We examine this using two different causal structures (common cause/common effect) and two different scenarios (agent‐based/mechanical). In the first, participants must update their estimate of the propensity for two warring nations to successfully explode missiles after being told of a new explosion on the border between both nations. In the second, participants must update their estimate of the (...) accuracy of two early warning tests for cancer when they produce conflicting reports about a patient. Across both experiments, we find two modal responses, representing around one‐third of participants each. In the first, “Categorical” response, participants update propensity estimates as if they were certain about the single event, for example, certain that one of the nations was responsible for the latest explosion, or certain about which of the two tests is correct. In the second, “No change” response, participants make no update to their propensity estimates at all. Across the three experiments, the theory is developed and tested that these two responses in fact have a single representation of the problem: because the actual outcome is binary (only one of the nations could have launched the missile; the patient either has cancer or not), these participants believe it is incorrect to update propensities in a graded manner. They therefore operate on a “certainty threshold” basis, whereby, if they are certain enough about the single event, they will make the “Categorical” response, and if they are below this threshold, they will make the “No change” response. Ramifications are considered for the “categorical” response in particular, as this approach produces a positive‐feedback dynamic similar to that seen in the belief polarization/confirmation bias literature. (shrink)

These forty-five short tales about workers’ lives, originally published in British socialist periodicals between 1884 and 1914, differ strikingly from the narrative that most contemporary labor and...

What happens to scientific knowledge when researchers outside the natural sciences bring elements of the latest trend across disciplinary boundaries for their own purposes? Researchers in fields from anthropology to family therapy and traffic planning employ the concepts, methods, and results of chaos theory to harness the disciplinary prestige of the natural sciences, to motivate methodological change or conceptual reorganization within their home discipline, and to justify public policies and aesthetic judgments. Using the recent explosion in the use of chaos (...) theory, _Borrowed Knowledge and the Challenge of Learning across Disciplines _examines the relationship between science and other disciplines as well as the place of scientific knowledge within our broader culture. Stephen H. Kellert’s detailed investigation of the myriad uses of chaos theory reveals serious problems that can arise in the interchange between science and other knowledge-making pursuits, as well as opportunities for constructive interchange. By engaging with recent debates about interdisciplinary research, Kellert contributes a theoretical vocabulary and a set of critical frameworks for the rigorous examination of borrowing. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Perceiving Particulars Blindly:Remarks on a Nyāya-Buddhist ControversyStephen H. PhillipsIntroductionThe discussion by Mark Siderits in this issue—"Perceiving Particulars"—and two pieces by Monima Chadha—the first her article "Perceptual Cognition: A Nyāya-Kantian Approach" (Chadha 2001) and the second her reply to Siderits in this issue—have taught me much.1 I have little to add beyond agreeing on the whole with Siderits and making a few tweaks concerning Nyāya. Chadha astutely captures the insight (...) of Gaṅgeśa, the fourteenth-century Naiyāyika cited by her (and by Siderits): indeterminate perception does not have a "particular as such" as its object (viṣaya), but only, as she says, a non-particular individual such as a universal or another qualifier that is in principle recurrent (recurrent out in the world), perceivable [End Page 389] again, and thus expressible by a (repeatable) word. Nevertheless, the holism of Wilfred Sellars and Kant and the attack on the "given" are not in the spirit of the Nyāya approach to epistemology, which is thoroughly externalist, as Siderits suggests. In several places (one presented below), Gaṅgeśa shows us controversy within Nyāya about indeterminate perception, including a rival Naiyāyika opinion that bare particulars are indeterminately grasped. This is not his own view, which is that positing indeterminate perception of qualifiers and not also of qualificanda is all that we need. But all in all the issue is not such a big deal, since perception does generate determinate knowledge of particulars, although these are always at least barely clothed.The notion of a "bare particular"—that is, the qualificandum thought about as distinct from all of its qualifiers—is an abstraction from what we directly perceive. We know it only by inference (specifically, by an inference of the sāmānyato dṘṣṭa type). Indeterminate perception is also known only by inference. Even in Navya Nyāya, the big deal is what is known determinately in perception, which is the principal way we know anything (the jyeṣṭa pramāṇa). And, clearly, determinate perceptual awareness is often of a particular—"The pot is blue" and "That's a pot," for instance. The particular known—indeed, the bare particular—is an intrinsic part of the viṣayatā, "intentionality," which is the relation between the knowing cognition and the world known.2Contrary to what Chadha says in her first article, "seeing as" does not require mental construction, according to Nyāya. The property bearer (dharmin = viśeṣya, "qualificandum") is grasped by the sense organ and is known directly in determinate perception as well as the qualifier and the qualificative relation. In two subtypes of perceptual awareness, (a) recurrent experience and (b) the recognition of something perceived previously, Chadha is right: the mind is operative, responsive to the firing of saṃskāra, "memory impressions," and fusing previous perceptual data into a current perceiving: (a) "A cow," "Another," "Another," and (b) "This is that Devadatta (I saw yesterday)." But hardly all cases of determinate perception require the mind (in Chadha's sense). The object known is minimally a complex of a property bearer (the particular as such), property, and an ontological relation tying them up, a-inherence-pothood (where "a" designates the pot as bare particular, "the subject of qualification"); the determinate perception, "That's a pot," makes that particular as qualified known.So, you say, I am agreeing with Chadha, whose argument is directed against the particular as such being known (either determinately or indeterminately) in perception. Yes, but the point is that the particular is known in perception; the particular-as-such is known in perception, although it would be fantasy to think it even possible that we could ever see her, this property bearer, well, not so much bare as disembodied. A rough analogy is seeing a door. We say we "see the door" when we see only one side of it, not the back. We see the thing as a door without grasping everything about the door that its being a door entails.Indeterminate perception of qualifiers is a controversial posit that does various work for Gaṅgeśa and other... (shrink)

Classical Indian views of the self and person range from maximal to minimal conceptions, from a view of everyone's true self as the supreme being, infinite, immortal, self‐existent, self‐aware, and intrinsically blissful, to a view of the person as nothing more than the living human body that ceases to be at death. (“Consciousness is an adventitious attribute of the body, like the intoxicating power of fermented grain.”) Every major school and subschool takes a stance on what a self is and (...) how it is known; a rich diversity of opinion and argument marks this area of classical Indian thought. (shrink)

Study of Upādhiprakaraṇa of Gaṅgeśa, 13th cent., treatise on Navya Nyāya philosophy; includes text and translataion.

Berkeley’s appeal to a posteriori arguments for God’s existence supports belief only in a God who is finite. But by appealing to an a priori argument for God’s existence, Berkeley emphasizes God’s infinity. In this latter argument, God is not the efficient cause of particular finite things in the world, for such an explanation does not provide a justification or rationale for why the totality of finite things would exist in the first place. Instead, God is understood as the creator (...) of the total unity of all there is, the whole of creation. In this a priori argument, we should not focus on the specific objects that God creates, for that requires that we think that God knows each finite thing as distinct from every other. Rather, we should recognize how God creates all things in creating the complex, infinite totality of finite perceivings, each of which exists in virtue of the distinctions and relations it expresses. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:“The Whole Internal World His Own”: Locke and Metaphor ReconsideredS. H. ClarkWhy need I name thy Boyle, whose pious search, Amid the dark recesses of his works, The great Creator sought? And why thy Locke, Who made the whole internal world his own?Oh decus! Anglicae certe oh lux altera gentis!... Tu caecas rerum causas, fontemque severum Pande, Pater; tibi enim, tibi, veri magne Sacerdos, Corda patent hominum, atque altae (...) penetralia Mentis.Fourfold Annihilation & at the clangor of the Arrows of Intellect The innumerable Chariots of the Almighty appeard in Heaven And Bacon & Newton & Locke, & Milton & Shakespear & Chaucer1Two features of these encomia to John Locke, composed by James Thomson, Thomas Gray, and William Blake, are immediately striking. Firstly, they are delivered by poets in a tradition customarily seen as a reaction to the intellectual climate induced by Locke’s Essay, a book which Blake famously claimed to regard with “Contempt and Abhorrence.” 2 Secondly, the familiar and somewhat hackneyed characterizations of Locke as philosopher of common-sense, [End Page 241] empiricism, and liberal ideology are refreshingly absent. For Gray he is “veri magne Sacerdos,” great priest of truth; Thomson places him in a pantheon including Shakespeare, Milton, Spenser, and Chaucer; and this ranking is explicitly endorsed in Blake’s “Milton & Shakspear & Chaucer.” Comparable praise of Locke’s imaginative power is conspicuously absent from even the most generous tributes of recent commentators. 3Even if Locke’s philosophical contribution to a variety of debates is fully acknowledged, the question remains of why his major work, An Essay concerning Human Understanding, was held in such high popular esteem—veneration is not too strong a word—during the subsequent century. The text itself appears an improbable candidate for such canonization: George Saintsbury accused its prose of being “positively mean in every point of style,” 4 and certainly in comparison with the poised and lucid ironies of Berkeley and Hume, it cannot but appear prolix, diffuse, and repetitive. The chief (and frequently only) merit grudgingly accorded to it is of disarming informality. Rosalie Colie’s emphasis on the “exploitation of the generic and rhetorical possibilities in the essay form itself “ highlights the conscious manipulation of authorial distance through which Locke creates the effect of sprawling inclusiveness and incom-pletion, but at the expense of conceding that “in exchange for the frankness with which the essayist appeared to present his thinking self, he was allowed certain liberties from logical rigour.” 5 Though the suggestion that a major philosophical text seeks to evade “logical rigour” might seem damning enough, there is a still more insidious equation of Locke’s “middle-style,” his desire “to make, what I have to say, as easie and intelligible to all sort of Readers as I can,” with a complicity with the expectations of his audience. 6 Other critics, notably John Richetti, have put a more positive gloss on the “simple and fortuitously concocted circle of friends” to whom the Essay is addressed, but even these accounts have been obliged to stress the representative and consensual nature of Locke’s thought. 7 This view is perhaps most elegantly expressed by Leslie Stephen: “Locke ruled the thought of his own and the coming period [End Page 242] because he interpreted so completely the fundamental beliefs which had been worked out at this time. He ruled, that is, by obeying.” 8William Walker correctly observes that “identifying and interpreting metaphors of mind” in the Essay are “standard practices of mainstream philosophical commentary from Leibniz to Rorty,” but also notes that these analyses are usually concerned with the degree to which Locke’s reliance on figuration was at variance with and compromised his epistemological doctrine. 9 I would argue that the poetic tributes previously quoted offer a more suggestive and adequate guide to the original impact of his work. In order to substantiate this claim, I shall begin by examining Locke’s apparent renunciation of, yet paradoxical dependence upon metaphor; go on to look at the connection of the “Horizon” to the elegiac presentation of memory and the ethic of mental “Labour”; and conclude by analyzing the complex interdependence of candle and sun within the light imagery employed in the... (shrink)

This paper addresses a number of issues concerning both the status of phenomenology in the work of one of its classical expositors, Maurice Merleau-Ponty, and the general relation between theoretical models and evidence in phenomenological accounts. In so doing, I will attempt to explain Merleau-Ponty's departure from classical transcendental accounts in Husserl's thought and why Merleau-Ponty increasingly elaborated on them through aesthetic rationality. The result is a phenomenology that no longer understands itself as foundational and no longer understands itself in (...) the strict opposition of intuition and concept. Rather both emerge from an operative experience generated in the exchange between situated embodied knowing and historical knowledge. (shrink)

This paper investigates the role of literature and, in particular, Proust in Merleau-Ponty’s late works’ rehabilitation of the ontology of the sensible. First, I trace Proust’s role in Phenomenology of Percpetion, contrasting it with the somewhat more paradigmatic status as a model it plays in the late works. Second, I compare this with the role of the novel as partial myth in Schelling, who also played an essential role in Merleau-Ponty’s refiguration of the sensible. I briefly trace his examination of (...) the historical or “sociological meaning” of literature through works of the fifties, beginning with his Collège de France candidacy proposal and continuing through his examination of the rationality of modern disenchantment or dépoétization in the Adventures of the Dialectic. Finally, discussing the late analysis of Proust against this backdrop, I conclude with considerations concerning the relevance of Merleau-Ponty’s overall analysis of Proust both in his thought and contemporary literary criticism and philosophy more generally. Cet article examine le rôle de la littérature et, en particulier, celui de Proust, dans la réhabilitation ontologique du sensible qui se trame dans les derniers écrits de Merleau-Ponty. En premier lieu, je retracerai le rôle de Proust dans la Phénoménologie de la perception, en l’opposant au statut quelque peu plus paradigmatique, comme s’il s’agissait d’un modèle, qu’il joue dans le dernier Merleau-Ponty. Deuxièmement, je comparerai cela avec la fonction du roman conçu comme un mythe incomplet chez Schelling, qui a aussi joué un rôle essentiel dans la reconfiguration du sensible chez Merleau-Ponty. Je décrirai brièvement son analyse de la « signification sociologique » ou historique de la littérature à travers des oeuvres des années ’50, en me penchant, d’abord, sur sa candidature au Collège de France, et, ensuite, sur son étude de la rationalité du désenchantement moderne ou dépoétisation dans les Aventures de la dialectique. Finalement, en examinant les dernières analyses de Proust à partir de ces prémisses, je conclurai avec des considérations sur l’intérêt de l’ensemble de l’analyse que Merleau-Ponty fait de Proust à la fois pour sa pensée, pour la critique littéraire contemporaine et, plus généralement, pour la philosophie.Il presente articolo indaga il ruolo della letteratura e, in particolare, di Proust nella riabilitazione ontologica del sensibile negli ultimi scritti di Merleau-Ponty. In primo luogo, si delinea il ruolo di Proust nella Fenomenologia della percezione, contrapponendolo, in qualche modo, allo statuto paradigmatico di modello che l’autore riveste nei lavori dell’ultimo Merleau-Ponty. In secondo luogo, si confronta questo con il ruolo del romanzo come mito parziale in Schelling, che pure ha giocato una parte essenziale nella rifigurazione del sensibile in Merleau-Ponty. Si articolerà brevemente il significato storico o sociologico della letteratura attraverso gli scritti degli anni Cinquanta, a partire dalla proposta di candidatura di Merleau-Ponty al Collège de France e proseguendo mediante il suo esame della razionalità del disincanto moderno o depoetizzazione ne Le avventure della dialettica. Infine, esaminando l’ultima lettura di Proust a partire da queste analisi, propongo una considerazione riguardo alla rilevanza complessiva dell’autore della Recherche nella riflessione di Merleau-Ponty e, più in generale, nella critica letteraria e nella filosofia contemporanee. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.4 (2003) iv [Access article in PDF] Editors' Remarks I am pleased to announce that Gerard Hauser will assume the editorship of Philosophy and Rhetoric. Professor Hauser has been closely associated with the journal for decades, and I can think of no one better suited to realizing its distinctive mission. I wish to express my heartfelt gratitude to the many authors and reviewers who have contributed (...) to the achievement of this journal. Henry, be assured, would have been pleased. Stephen H. Browne * * *Assuming the editorship of Philosophy and Rhetoric is a joyous return to a prior calling. My association with the journal as its book review editor, as Donald Verene's associate editor, and as Henry Johnstone's co-editor marked active engagement in the first quarter-century of its contribution to the ancient dialogue reflected in its name. I am honored to have been asked to succeed Stephen Browne, who has provided a decade of leadership in sustaining the journal's high standards. As editor, my intention is to continue Philosophy and Rhetoric's tradition of advancing deep scholarship and new thought in the areas reflected in its statement of purpose. Gerard A. Hauser... (shrink)